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The lead reviewers for Pancreatic Cancer Treatment are. BACKGROUND An Investigational New Drug (IND) treatment program allows patients access to a drug that has shown activity against a serious or life- threatening disease prior to full Food and Drug Administration (FDA) review and. An investigational new drug treatment program for patients with gemcitabine. Studies to evaluate gemcitabine in patients with earlier stages of pancreatic carcinoma and to evaluate gemcitabine in combination with surgery. Pancreatic Cancer Treatment (PDQ.
Randomized Studies in Stage III Pancreatic Cancer: Median Survival continued. Treatment Options Under Clinical Evaluation for Stage III Pancreatic Cancer. Treatment options under clinical evaluation include the following: For patients with unresectable tumors, clinical trials evaluating novel agents in combination with chemotherapy or chemoradiation therapy (RTOG- PA- 0. Intraoperative radiation therapy and/or implantation of radioactive sources. Current Clinical Trials. Author information: (1)Lilly Research Laboratories, Indianapolis, Indiana 4. USA. BACKGROUND: An Investigational New Drug (IND) treatment program.
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A phase II study of weekly cisplatin and gemcitabine in patients with advanced. Storniolo AM, Enas NH, Brown CA, Schilsky R. Treatment investigational new drug program for Gemzar (gemcitabine HCl) in patients. Treatment Options Under Clinical Evaluation for Stage III Pancreatic Cancer.
An investigational new drug treatment program for patients. An investigational new drug treatment program for patients. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. General information about clinical trials is also available from the NCI Web site. References: Iacobuzio- Donahue CA, Fu B, Yachida S, et al.: DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer.
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Bosch RP, van der Schelling GP, Klinkenbijl JH, et al.: Guidelines for the application of surgery and endoprostheses in the palliation of obstructive jaundice in advanced cancer of the pancreas. Ann Surg 2. Baron TH: Expandable metal stents for the treatment of cancerous obstruction of the gastrointestinal tract. N Engl J Med 3. Sohn TA, Lillemoe KD, Cameron JL, et al.: Surgical palliation of unresectable periampullary adenocarcinoma in the 1. A multi- institutional comparative trial of radiation therapy alone and in combination with 5- fluorouracil for locally unresectable pancreatic carcinoma.
The Gastrointestinal Tumor Study Group. Cohen SJ, Dobelbower R Jr, Lipsitz S, et al.: A randomized phase III study of radiotherapy alone or with 5- fluorouracil and mitomycin- C in patients with locally advanced adenocarcinoma of the pancreas: Eastern Cooperative Oncology Group study E8.
Int J Radiat Oncol Biol Phys 6. Chauffert B, Mornex F, Bonnetain F, et al.: Phase III trial comparing initial chemoradiotherapy (intermittent cisplatin and infusional 5- FU) followed by gemcitabine vs. Loehrer PJ Sr, Feng Y, Cardenes H, et al.: Gemcitabine alone versus gemcitabine plus radiotherapy in patients with locally advanced pancreatic cancer: an Eastern Cooperative Oncology Group trial. Moertel CG, Frytak S, Hahn RG, et al.: Therapy of locally unresectable pancreatic carcinoma: a randomized comparison of high dose (6. The Gastrointestinal Tumor Study Group. Cancer 4. Chauffert B, Mornex F, Bonnetain F, et al.: Phase III trial comparing intensive induction chemoradiotherapy (6. Gy, infusional 5- FU and intermittent cisplatin) followed by maintenance gemcitabine with gemcitabine alone for locally advanced unresectable pancreatic cancer.
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Definitive results of the 2. Rothenberg ML, Moore MJ, Cripps MC, et al.: A phase II trial of gemcitabine in patients with 5- FU- refractory pancreas cancer. Burris HA 3rd, Moore MJ, Andersen J, et al.: Improvements in survival and clinical benefit with gemcitabine as first- line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1. Storniolo AM, Enas NH, Brown CA, et al.: An investigational new drug treatment program for patients with gemcitabine: results for over 3. Moore MJ, Goldstein D, Hamm J, et al.: Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group.
Poplin E, Feng Y, Berlin J, et al.: Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed- dose rate infusion) compared with gemcitabine (3. Eastern Cooperative Oncology Group. Colucci G, Labianca R, Di Costanzo F, et al.: Randomized phase III trial of gemcitabine plus cisplatin compared with single- agent gemcitabine as first- line treatment of patients with advanced pancreatic cancer: the GIP- 1 study. Von Hoff DD, Ervin T, Arena FP, et al.: Increased survival in pancreatic cancer with nab- paclitaxel plus gemcitabine. N Engl J Med 3. Conroy T, Desseigne F, Ychou M, et al.: FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. Pelzer U, Kubica K, Stieler J, et al.: A randomized trial in patients with gemcitabine refractory pancreatic cancer. Final results of the CONKO 0.
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Pelzer U, Schwaner I, Stieler J, et al.: Best supportive care (BSC) versus oxaliplatin, folinic acid and 5- fluorouracil (OFF) plus BSC in patients for second- line advanced pancreatic cancer: a phase III- study from the German CONKO- study group. Tepper JE, Noyes D, Krall JM, et al.: Intraoperative radiation therapy of pancreatic carcinoma: a report of RTOG- 8. Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 2. Reni M, Panucci MG, Ferreri AJ, et al.: Effect on local control and survival of electron beam intraoperative irradiation for resectable pancreatic adenocarcinoma.
Int J Radiat Oncol Biol Phys 5.